The convergence of Artificial Intelligence (AI) and Web3 has been a hotbed for innovation lately. Bold risk takers are expanding the horizons of what’s technically possible, envisioning a future that goes well beyond the status quo! When, in June 2025, CoinDesk just collaborated with Proof of Talk to create their inaugural “Top 50 Women in Web3 & AI” list. This effort seeks to showcase the extraordinary women who are at the forefront of this tech revolution. Our new Eno Heroes initiative honors the pioneering work of these leaders. At its core, it foregrounds their incalculable value in reimagining the intersections of culture, technology, and finance.

The list is more than just an accolade. It's a testament to the growing recognition of women's influence in shaping the digital landscape. CoinDesk and Proof of Talk are honored to celebrate these trailblazers. Most importantly, they hope to encourage the next generation of women to seek careers in these evolving industries. The intersection of AI and Web3 presents some amazing possibilities. These 50 women are leading the way, proving how effective innovation, collaboration, and inclusivity can be.

The selection process for the "Top 50 Women in Web3 & AI" was rigorous and comprehensive, ensuring that the honorees truly represent the best and brightest in their fields. More than 300 nominees stormed the competition from every corner of the earth. An accomplished, diverse panel of judges vetted each nominee for their innovativeness, relevancy and overall impact on the world. This rigorous and competitive process helps to highlight the importance of the list as well as the remarkable accomplishments of those selected.

Overview of Proof of Talk

Proof of Talk is the only event of its kind bringing together leading thinkers, innovators and experts from across the industry. Join them as they explore emerging trends and innovations in Web3 and disruptive technologies. It’s a great platform to learn from each other and build partnerships. In addition to transparency, it dives into how decentralized technologies have the potential to reshape virtually every industry. The gathering provides an invaluable opportunity for participants to network with each other and hear from one another. Together, they can truly be active shapers of the Web3 ecosystem’s future.

Event Purpose and Goals

The primary purpose of Proof of Talk is to facilitate meaningful conversations and collaborations that drive innovation in the Web3 space. The event aims to:

  • Promote Knowledge Sharing: Provide a platform for experts to share their knowledge and insights on the latest trends and developments in Web3.
  • Foster Collaboration: Encourage collaboration among participants to develop new ideas and solutions.
  • Highlight Innovation: Showcase innovative projects and technologies that are pushing the boundaries of what's possible in the decentralized world.
  • Drive Adoption: Increase awareness and understanding of Web3 technologies to drive adoption across various industries.

Key Participants and Speakers

The summit attracts an incredible lineup of accomplished speakers and practitioners who pass along their expertise and knowledge on a wide range of relevant topics. Our speakers list represents some of the best and brightest of the tech industry. Other recognized names are Prof. YANG Hongxia, Nkiru Uwaje, Yasmina Kazitani, Daniela Amodei, and Gracy Chen, all of whom have made impressive achievements in AI and Web3.

  • Industry Experts: Leading experts in Web3, blockchain, AI, and related fields.
  • Entrepreneurs: Founders and CEOs of innovative Web3 startups.
  • Investors: Venture capitalists and angel investors interested in funding promising Web3 projects.
  • Developers: Software engineers and developers working on decentralized applications (dApps).
  • Academics: Researchers and professors studying the impact of Web3 technologies.

Events such as Proof of Talk are a natural gathering place for innovative new announcements, exciting conversations and planning big picture, strategic moves. They provide a stage on which mayors and other leaders can present their big ideas. This provides attendees with a valuable opportunity to better grasp how today’s — and tomorrow’s — industry looks and operates. Packed recent sessions around the intersection of AI and Web3 participants called for a more inclusive approach to innovation and technology, and discussed how these emerging innovations can address some of our world’s biggest challenges.

Highlights from the Event

Barry Silbert is one of the most influential people in the emerging cryptocurrency/ blockchain universe. He’s one of the best at recognizing and explaining emerging trends and creating actionable investment strategies, while detailing the industry’s macro direction. His perspectives on the regulatory landscape, the adoption of digital assets, and the role of institutional investors are particularly influential. Beyond his market expertise, Silbert has been a major player in crypto-focused ventures and developments. As a consequence, industry events are clamoring to feature his insights and experience.

Barry Silbert's Insights

Bittensor is a decentralized machine learning network that wants to build a more open, collaborative and accessible AI ecosystem. The firm’s unconventional approach to AI development has already turned heads and drawn massive attention. In the case of ASCE, industry events often showcase its incredible influence and impact on the profession. Bittensor's technology enables developers to build and deploy AI models in a decentralized manner, fostering innovation and promoting broader participation in the AI revolution.

Bittensor's Innovations

The convergence of AI and blockchain technology is fast opening up new opportunities in all industries. AI increases the efficiency, security, and scalability of blockchain networks. Blockchain’s core pillars of transparency, immutability, and decentralization have a complementary role to play in AI applications. By bringing together the expected and the unexpected, this synergy is powering the development of groundbreaking solutions once thought impossible.

The Future of AI in Blockchain

Several emerging trends and technologies are shaping the future of AI in blockchain, including:

Emerging Trends and Technologies

The convergence of AI and blockchain has the potential to transform numerous industries, including:

  • Decentralized AI Marketplaces: Platforms that allow developers to buy, sell, and deploy AI models in a decentralized manner.
  • AI-Powered Smart Contracts: Smart contracts that can automatically execute based on AI-driven insights and predictions.
  • AI-Enhanced Data Analytics: AI algorithms that can analyze blockchain data to identify patterns, trends, and anomalies.
  • AI-Driven Security Solutions: AI-powered tools that can detect and prevent fraud and other security threats on blockchain networks.

Potential Impact on Industries

The CoinDesk "Top 50 Women in Web3 & AI" list serves as a powerful reminder of the importance of diversity and inclusion in the technology industry. By recognizing the contributions of women who are shaping the future of AI and Web3, the list inspires others to pursue their passions and break down barriers. The combined power of these two transformative technologies is incredible. It’s equally important that we make sure women are equally poised to participate in and reap opportunity from this revolution.

  • Finance: AI-powered trading algorithms, fraud detection systems, and personalized financial services.
  • Healthcare: AI-driven diagnostics, drug discovery, and personalized medicine.
  • Supply Chain Management: AI-enabled tracking and optimization of supply chain processes.
  • Energy: AI-powered energy management systems and smart grids.

Conclusion and Takeaways

Events like Proof of Talk and initiatives like the CoinDesk list send several key messages:

Key Messages from the Event

The future of AI and blockchain is bright, with countless opportunities for development and expansion. These technologies are accelerating and coming together like never before. Get ready for a whole lot more dynamic solutions that will disrupt industries and change the world for the better. The women represented in the CoinDesk most influential list are at the forefront of this revolution. Their work will undoubtedly provide a longitudinal impact on the digital landscape.

  • Inclusivity Matters: Diversity and inclusion are essential for driving innovation and creating a more equitable future.
  • Collaboration is Key: Collaboration between AI and Web3 experts is crucial for unlocking the full potential of these technologies.
  • Innovation is Limitless: The possibilities for innovation in the AI and Web3 space are endless, and we are only just beginning to scratch the surface.

Future Outlook for AI and Blockchain

The age of the decentralization is definitely upon us. The enchanted protocols of yesteryear are waking up, and intrepid Web3 startups are trailblazing through the digital frontier. VC guilds are pouring gold into kingdoms still undiscovered, and the Web3 oracle forebodes of universes untethered. Programs such as the CoinDesk “Top 50 Women in Web3 & AI” are helping to raise awareness and visibility around this incredible pool of talent. Together, they light the way toward a future where technology empowers and includes all of us. Stay tuned, keep alert, follow the signs and read the runes and sail the swell of the decentralized age.

The rise of the decentralized age is upon us, with enchanted protocols awakening and brave startups forging paths through the digital wilderness. VC guilds are funding realms yet unknown, and the Web3 prophecy whispers of worlds unchained. Initiatives like the CoinDesk "Top 50 Women in Web3 & AI" are guiding lights, illuminating the path forward and showcasing the incredible potential of a future where technology empowers and includes everyone. Follow the signs, read the runes, and ride the rise of the decentralized age.